Asthma

Research

(2010) Occurrence of Chlamydia trachomatis and Chlamydia pneumoniae in paediatric respiratory infections

W.C. Webley*, Y. Tilahun*, K. Lay*, K. Patel*, E.S. Stuart*, C. Andrzejewski# and P.S. Salva"

(2010) Infectious Chlamydia pneumoniae is Associated With ElevatedInterleukin-8 and Airway Neutrophilia in Children With Refractory Asthma

Katir K. Patel, MS,* Alfin G. Vicencio, MD,† Zhongfang Du, MD,† Kalliope Tsirilakis, MD,†Paul S. Salva, MD, PhD,‡ and Wilmore C. Webley, PhD*

Secondary outcome of a Pilot Randomized study of Azithromycin Treatment for Asthma

David L. Hahn, Mary Beth Plane, Olaimatu S. Mahdi, Gerald I. Byrne

The respiratory pathogen Chlamydia pneumoniae (C. pneumoniae) produces acute and chronic lung infections and is associated with asthma. Evidence for effectiveness of antichlamydial antibiotics of performing in asthma clinical trial in practice settings where most asthma is encountered and managed. The secondary objectives were to investigate (1) wheter C. pneumoniae serology would be related to outcomes. This report presents the secondary results.

The Bronchial Lavage of Pediatric Patients with Asthma Contains Infectious Chlamydia

Wilmore C. Webley, Paul S. Salva, Chester Andrzejewski, Francis Cirino, Corrie A. West, Yaphet Tilahun, and Elizabeth S. Stuart

Department of Microbiology, University of Massachusetts, Amherst; and Department of Pathology and Pediatric Pulmonology, Baystate Medical Center, Springfield Massachusetts.

Increased frequency of detection of Chlamydophila pneumoniae in asthma

G.L. Biscione, J. Corne, A.J. Chauhan and S.L. Johnston

University Medicine, Southampton General Hospital, Southampton, and Dept of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, London, UK.

David L. Hahn and Mary Beth Plane
Feasibility of a Practical Clinical Trial for Asthma Conducted in Primary Care
J. Am. Board Fam. Pract., May 2004; 17: 190 - 195.

Azithromycin Improves Asthma Symptoms in Adults 3 months after treatment Hahn DL M.B. Plane Dean Medical Center, Madison, WI; Dept Fam Med, U Wisconsin Medical School, Madison, WI American Thoracic Society Abstracts of the 2004 International Conference.

(Please note the following isn't the full article but a scanned in abstract)

Chlamydia pneumoniae (Cpn)-Specific IgA antibody Level Predicts Subsequent Asthma Symptom Severity. Hahn DL M.B. Plane Dean Medical Center, Madison, WI; Dept Fam Med, U. Wisconsin Medical School, Dept Mol Sci U Tennessee Health Sci Cir, Memphis Tn. Abstracts of the 2004 International Conference.

(Please note the following isn't the full article but a scanned in abstract)

Treatment of Chlamydia pneumoniae infection in adult asthma: A before-after trial. Hahn DL J Fam Pract (1995 Oct) 41(4):345-51 ISSN: 0094-3509

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excellent article

Detection of anti-Chlamydia pneumoniae IgE in children with reactive airway disease. Emre U, Sokolovskaya N, Roblin PM, Schachter J, Hammerschlag MR J Infect Dis (1995 Jul) 172(1):265-7 ISSN: 0022-1899

Can acute Chlamydia pneumoniae respiratory tract infection initiate chronic asthma? Hahn DL, McDonald R Ann Allergy Asthma Immunol (1998 Oct) 81(4):339-44 ISSN: 1081-1206

Evidence for Chlamydia pneumoniae infection in steroid-dependent asthma.
Hahn DL, Bukstein D, Luskin A, Zeitz H Ann Allergy Asthma Immunol (1998 Jan) 80(1):45-9 ISSN: 1081-1206

Asthma and chlamydial infection: a case series.
Hahn DL, Golubjatnikov R J Fam Pract (1994 Jun) 38(6):589-95 ISSN: 0094-3509

Association of Chlamydia pneumoniae (strain TWAR) infection with wheezing, asthmatic bronchitis, and adult-onset asthma.
Hahn DL, Dodge RW, Golubjatnikov JAMA (1991 Jul 10) 266(2):225-30 ISSN: 0098-7484

Acute exacerbations of asthma in adults: role of Chlamydia pneumoniae infection. Allegra L, Blasi F, Centanni S, Cosentini R, Denti F, Raccanelli R, Tarsia P Valenti V Eur Respir J (1994 Dec) 7(12):2165-8 ISSN: 0903-1936

Asthma Susceptibility in Chlamydia-Infected Children Depends on Serum Protein. NEW YORK (Reuters Health) Nov 06 2003
An immune defense protein, known as mannose-binding lectin (MBL), plays a key role in determining asthma susceptibility in children infected with Chlamydia pneumoniae

Trial of roxithromycin in subjects with asthma and serological evidence of infection with Chlamydia pneumoniae.
Black PN, Blasi F, Jenkins CR, Scicchitano R, Mills GD, Rubinfeld AR Ruffin RE, Mullins PR, Dangain J, Cooper BC, David DB, Allegra L Am J Respir Crit Care Med (2001 Aug 15) 164(4):536-41 ISSN: 1073-449X

Increased frequency of Chlamydia pneumoniae antibodies in patients with asthma.
Gencay M, Rudiger JJ, Tamm M, Soler M, Perruchoud AP, Roth M Am J Respir Crit Care Med (2001 Apr) 163(5):1097-100 ISSN: 1073-449X

Persistent airflow limitation in adult-onset nonatopic asthma is associated with serologic evidence of Chlamydia pneumoniae infection.

ten Brinke A, van Dissel JT, Sterk PJ, Zwinderman AH, Rabe KF, Bel EH J Allergy Clin Immunol (2001 Mar) 107(3):449-54 ISSN: 0091-6749

Detection of Mycoplasma pneumoniae in the airways of adults with chronic asthma
[published erratum appears in Am J Respir Crit Care Med 1998 Nov;158(5 Pt 1):1692]Kraft M, Cassell GH, Henson JE, Watson H, Williamson J, Marmion BP Gaydos CA, Martin RJ Am J Respir Crit Care Med (1998 Sep) 158(3):998-1001 ISSN: 1073-449X

The association of Chlamydia pneumoniae infection and reactive airway disease in children.
Emre U, Roblin PM, Gelling M, Dumornay W, Rao M, Hammerschlag MR Schachter J Arch Pediatr Adolesc Med (1994 Jul) 148(7):727-32 ISSN: 1072-4710

Serologic markers for Chlamydia pneumoniae in asthma.
Hahn DL, Peeling RW, Dillon E, McDonald R, Saikku P Ann Allergy Asthma Immunol (2000 Feb) 84(2):227-33 ISSN: 1081-1206

Chlamydia pneumoniae, asthma, and COPD: what is the evidence?
Hahn DL Ann Allergy Asthma Immunol (1999 Oct) 83(4):271-88, 291; quiz 291-2 ISSN: 1081-1206

Comparison of two serological methods and a polymerase chain reaction- enzyme immunoassay for the diagnosis of acute respiratory infections with Chlamydia pneumoniae in adults.
Petitjean J, Vincent F, Fretigny M, Vabret A, Poveda JD, Brun J, Freymuth F J Med Microbiol (1998 Jul) 47(7):615-21 ISSN: 0022-2615

Chlamydia pneumoniae and exacerbations of asthma in adults.
Miyashita N, Kubota Y, Nakajima M, Niki Y, Kawane H, Matsushima T Ann Allergy Asthma Immunol (1998 May) 80(5):405-9 ISSN: 1081-1206

Association of Chlamydia pneumoniae IgA antibodies with recently symptomatic asthma.
Hahn DL, Anttila T, Saikku P Epidemiol Infect (1996 Dec) 117(3):513-7 ISSN: 0950-2688

Host immune response to Chlamydia pneumoniae heat shock protein 60 is associated with asthma.
Huittinen T, Hahn D, Anttila T, Wahlstrom E, Saikku P, Leinonen M Eur Respir J (2001 Jun) 17(6):1078-82 ISSN: 0903-1936

Importance of acute Mycoplasma pneumoniae and Chlamydia pneumoniae infections in children with wheezing .
Esposito S, Blasi F, Arosio C, Fioravanti L, Fagetti L, Droghetti R Tarsia P, Allegra L, Principi N Eur Respir J (2000 Dec) 16(6):1142-6 ISSN: 0903-1936

Chronic Chlamydia pneumoniae infection in patients with asthma.

Przewlekle zakazenie Chlamydia pneumoniae u chorych na astme oskrzelowa.Niedzwiadek J, Mazur E, Chmielewska-Badora J, Gryglicka B Wegrzyn-Szkutnik I, Chabros B, Koziol-Montewka M, Milanowski J Pneumonol Alergol Pol (2000) 68(5-6):255-60 ISSN: 0867-7077

Impact of Chlamydia pneumoniae infections on asthma.
Impact des infections a Chlamydia pneumoniae sur la maladie asthmatique. Jebrak G, Brugiere O, Uffredi ML Presse Med (2000 Sep 9) 29(25):1425-31 ISSN: 0755-4982

Chlamydia pneumoniae infection in patients with acute bronchitis and bronchial asthma.
Oshima M, Awaya Y, Fujii T, Kodomari Y, Kuwabara M Arerugi (2000 May) 49(5):412-9 ISSN: 0021-4884

Chlamydia pneumoniae serological status is not associated with asthma in children or young adults.
Mills GD, Lindeman JA, Fawcett JP, Herbison GP, Sears MR Int J Epidemiol (2000 Apr) 29(2):280-4 ISSN: 0300-5771

Production of basic fibroblast growth factor and interleukin 6 by human smooth muscle cells following infection with Chlamydia pneumoniae.
Rodel J, Woytas M, Groh A, Schmidt KH, Hartmann M, Lehmann M, Straube E Infect Immun (2000 Jun) 68(6):3635-41 ISSN: 0019-9567

The role of atypical organisms in asthma.
Daian CM, Wolff AH, Bielory L Allergy Asthma Proc (2000 Mar-Apr) 21(2):107-11 ISSN: 1088-5412

Serological evidence of infection with Chlamydia pneumoniae is related to the severity of asthma.
Black PN, Scicchitano R, Jenkins CR, Blasi F, Allegra L, Wlodarczyk J Cooper BC Eur Respir J (2000 Feb) 15(2):254-9 ISSN: 0903-1936

Acute respiratory Chlamydia pneumoniae infections in adults. Value of direct gene amplification diagnosis. Infections respiratoires aigues de l'adulte a Chlamydia pneumoniae. Interet du diagnostic direct par amplification genique.

Vincent F, Petitjean J, Filmont JE, Le Moel G, Fontaine V, Vabret A Freymuth F, Brun J Rev Mal Respir (1999 Dec) 16(6):1131-7 ISSN: 0761-8425

Detection of viral, Chlamydia pneumoniae and Mycoplasma pneumoniae infections in exacerbations of asthma in children.
Freymuth F, Vabret A, Brouard J, Toutain F, Verdon R, Petitjean J, Gouarin S Duhamel JF, Guillois B J Clin Virol (1999 Aug) 13(3):131-9 ISSN: 1386-6532

Asthma, atopy and Chlamydia pneumoniae antibodies in adults.
Von Hertzen L, Toyryla M, Gimishanov A, Bloigu A, Leinonen M, Saikku P Haahtela T Clin Exp Allergy (1999 Apr) 29(4):522-8 ISSN: 0954-7894

The role of viral and atypical bacterial pathogens in asthma pathogenesis.
Johnston SL Pediatr Pulmonol Suppl (1999) 18:141-3 ISSN: 1054-187X

Chlamydia pneumoniae and possible relationship to asthma. Serum immunoglobulins and histamine release in patients and controls.
Larsen FO, Norn S, Mordhorst CH, Skov PS, Milman N, Clementsen P APMIS (1998 Oct) 106(10):928-34 ISSN: 0903-4641

Chlamydia pneumoniae infection in children with asthma exacerbation.
Kamesaki S, Suehiro Y, Shinomiya K, Matsushima H, Ouchi K Arerugi (1998 Jul) 47(7):667-73 ISSN: 0021-4884

Chlamydia pneumoniae and asthma.
Cook PJ, Davies P, Tunnicliffe W, Ayres JG, Honeybourne D, Wise R Thorax (1998 Apr) 53(4):254-9 ISSN: 0040-6376

Construction of an internal control for the detection of Chlamydia pneumoniae by PCR.
Ursi D, Ieven M, Van Bever HP, Goossens H Mol Cell Probes (1998 Aug) 12(4):235-8 ISSN: 0890-8508

Clinical aspects of chlamydia respiratory tract infections and their role in the pathogenesis of asthma. Kliniczne aspekty chlamydiowych zaka~zen ukladu oddechowego i ich rola w patogenezie astmy.Szulakowski P, Pierzchala W

Wiad Lek (1998) 51(3-4):202-7 ISSN: 0043-5147

Chronic Chlamydia pneumoniae infection and asthma exacerbations in children.
Cunningham AF, Johnston SL, Julious SA, Lampe FC, Ward ME Eur Respir J (1998 Feb) 11(2):345-9 ISSN: 0903-1936

Asthma and Chlamydia pneumoniae. A future prospect for macrolides in general and roxithromycin in particular? Asthme et Chlamydia pneumoniae. Une perspective d'avenir pour les macrolides en general et pour la roxithromycine en particulier?Mayaud C

Presse Med (1997 Mar) 26 Suppl 2:27-9 ISSN: 0755-4982

Chlamydiae as pathogens: new species and new issues.
Peeling RW, Brunham RC Emerg Infect Dis (1996 Oct-Dec) 2(4):307-19 ISSN: 1080-6040

Serology of chlamydia in relation to asthma and bronchial hyperresponsiveness.
Bjornsson E, Hjelm E, Janson C, Fridell E, Boman G Scand J Infect Dis (1996) 28(1):63-9 ISSN: 0036-5548

A link between chronic asthma and chronic infection Martin RJ, Kraft M, Chu HW, Berns EA, Cassell GH.

Association of Mycoplasma pneumoniae antigen with initial onset of bronchial asthma T Yano, Y Ichikawa, S Komatu, S Arai and K Oizumi

Can acute Chlamydia pneumoniae respiratory tract infection initiate chronic asthma? Hahn DL, McDonald R.

Chlamydia pneumoniae and chronic lung diseases Laurila AL, Von Hertzen L, Saikku P.

Chlamydia pneumoniae and severity of asthma Von HL, Vasankari T, Liippo K, Wahlström E, Puolakkainen M.

Chlamydia pneumoniae infection in patients with acute bronchitis and bronchial asthma Oshima M, Awaya Y, Fujii T, Kodomari Y, Kuwabara M.

Chlamydia pneumoniae infection of the central nervous system in multiple sclerosis Sriram S, Stratton CW, Yao S, Tharp A, Ding L, Bannan JD, Mitchell WM.

Chlamydophilapneumoniae and Mycoplasma pneumoniae in respiratory specimens of children with chronic lung diseases N Teig, A Anders, C Schmidt, C Rieger, S Gatermann

Evidence for Chlamydia pneumoniae infection in steroid-dependent asthma Hahn DL, Bukstein D, Luskin A, Zeitz H.

Importance of acute Mycoplasma pneumoniae and Chlamydia pneumoniae infections in children with wheezing Esposito S, Blasi F, Arosio C, Fioravanti L, Fagetti L, Droghetti R, Tarsia P, Allegra L, Principi N.

Mycoplasma and Chlamydia pneumonia in pediatrics Nelson CT.

Mycoplasma pneumoniae and Chlamydia pneumoniae cause lower respiratory tract disease in paediatric patients Principi N, Esposito S.

Prevalence of Mycoplasma pneumoniae infection in asthmatic adults in India Nazima Nisar, PhD, Randeep Guleria, MD, Arvind K. Singh, MD, Tirlok C. Chawla, PhD, Niranjan Nayak, MD and Nihar R. Biswas, MD

Prevalence of Chlamydia pneumoniae in acute respiratory tract infection and detection of anti-Chlamydia pneumoniae-specific IgE in Japanese children with reactive airway disease Ikezawa S.

Serologic markers for Chlamydia pneumoniae in asthma Hahn DL, Peeling RW, Dillon E, McDonald R, Saikku P.

The role of bacterial infections in asthma Kraft M.

Is Chlamydia pneumoniae important in asthma? The first controlled trial of therapy leaves the question unanswered.
Johnston SL Am J Respir Crit Care Med (2001 Aug 15) 164(4):513-4 ISSN: 1073-449X

Chlamydia pneumoniae antibodies and adult-onset asthma
Hahn DL J Allergy Clin Immunol (2000 Aug) 106(2):404 ISSN: 0091-6749

What determines asthma phenotype? Respiratory infections and asthma.
Douglass JA, O'Hehir RE Am J Respir Crit Care Med (2000 Mar) 161(3 Pt 2):S211-4 ISSN: 1073-449X

Chlamydia pneumoniae bacteria.
by Nancy Humphrey

Evidence is accumulating that many chronic ailments, including one that kills, are caused by bacteria
Scanned in from "The Economist" - 21st March 1998

Antibiotic slows atherosclerosis in people with Chlamydia pneumonia antibodies.
American Heart association

Pneumonia Organism May Play Role in MS Development.