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Secondary outcome of a Pilot Randomized study
of Azithromycin Treatment for Asthma
David L. Hahn, Mary Beth Plane, Olaimatu S. Mahdi, Gerald
I. Byrne
The respiratory pathogen Chlamydia pneumoniae (C. pneumoniae)
produces acute and chronic lung infections and is associated
with asthma. Evidence for effectiveness of antichlamydial
antibiotics of performing in asthma clinical trial in practice
settings where most asthma is encountered and managed. The
secondary objectives were to investigate (1) wheter C. pneumoniae
serology would be related to outcomes. This report presents
the secondary results.
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NEW August 2006 |
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The Bronchial Lavage of Pediatric Patients with
Asthma Contains Infectious Chlamydia
Wilmore C. Webley, Paul S. Salva, Chester Andrzejewski, Francis Cirino, Corrie A. West, Yaphet Tilahun, and Elizabeth S. Stuart
Department of Microbiology, University of Massachusetts, Amherst; and Department of Pathology and Pediatric Pulmonology, Baystate Medical Center, Springfield Massachusetts.
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Frequently
asked questions (FAQ)
Submitted by a member of the AsthmaStory.com forum |
79 |
Increased frequency of detection of Chlamydophila
pneumoniae in asthma
G.L. Biscione, J. Corne, A.J. Chauhan and S.L. Johnston
University Medicine, Southampton General Hospital, Southampton,
and Dept of Respiratory Medicine, National Heart and Lung
Institute, Imperial College London, London, UK.
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David L. Hahn and Mary Beth Plane
Feasibility of a Practical Clinical Trial for Asthma Conducted
in Primary Care
J. Am. Board Fam. Pract., May 2004; 17: 190 - 195.
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Azithromycin Improves Asthma Symptoms in Adults
3 months after treatment Hahn DL M.B.
Plane Dean Medical Center, Madison, WI; Dept Fam Med, U Wisconsin
Medical School, Madison, WI American Thoracic Society
Abstracts of the 2004 International Conference.
(Please note the following isn't the full article
but a scanned in abstract)
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Chlamydia pneumoniae (Cpn)-Specific IgA antibody
Level Predicts Subsequent Asthma Symptom Severity. Hahn
DL M.B. Plane Dean Medical Center, Madison, WI; Dept Fam Med,
U. Wisconsin Medical School, Dept Mol Sci U Tennessee Health
Sci Cir, Memphis Tn. Abstracts of the 2004 International Conference.
(Please note the following isn't the full article
but a scanned in abstract)
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NEW 7/2004 |
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1 |
Treatment of Chlamydia pneumoniae infection in
adult asthma: A before-after trial. Hahn
DL J Fam Pract (1995 Oct) 41(4):345-51 ISSN: 0094-3509
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excellent article |
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2 |
Detection of anti-Chlamydia pneumoniae IgE in children
with reactive airway disease. Emre U, Sokolovskaya
N, Roblin PM, Schachter J, Hammerschlag MR J Infect Dis (1995
Jul) 172(1):265-7 ISSN: 0022-1899 |
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3 |
Can acute Chlamydia pneumoniae respiratory tract
infection initiate chronic asthma? Hahn DL, McDonald
R Ann Allergy Asthma Immunol (1998 Oct) 81(4):339-44 ISSN:
1081-1206
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Evidence for Chlamydia pneumoniae infection in
steroid-dependent asthma.
Hahn DL, Bukstein D, Luskin A, Zeitz H Ann Allergy
Asthma Immunol (1998 Jan) 80(1):45-9 ISSN: 1081-1206
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Asthma and chlamydial infection: a case series.
Hahn DL, Golubjatnikov R J Fam Pract (1994 Jun) 38(6):589-95
ISSN: 0094-3509
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excellent article |
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Association of Chlamydia pneumoniae (strain TWAR)
infection with wheezing, asthmatic bronchitis, and adult-onset
asthma.
Hahn DL, Dodge RW, Golubjatnikov JAMA (1991 Jul
10) 266(2):225-30 ISSN: 0098-7484
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excellent article |
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Acute exacerbations of asthma in adults: role
of Chlamydia pneumoniae infection. Allegra L,
Blasi F, Centanni S, Cosentini R, Denti F, Raccanelli R, Tarsia
P Valenti V Eur Respir J (1994 Dec) 7(12):2165-8 ISSN: 0903-1936
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excellent article |
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74
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(NEW)
Asthma Susceptibility in Chlamydia-Infected
Children Depends on Serum Protein. NEW YORK (Reuters
Health) Nov 06 2003
An immune defense protein, known as mannose-binding lectin
(MBL), plays a key role in determining asthma susceptibility
in children infected with Chlamydia pneumoniae |
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Trial of roxithromycin in subjects with asthma
and serological evidence of infection with
Chlamydia pneumoniae.
Black PN, Blasi F, Jenkins CR, Scicchitano R, Mills GD,
Rubinfeld AR Ruffin RE, Mullins PR, Dangain J, Cooper BC,
David DB, Allegra L Am J Respir Crit Care Med (2001 Aug 15)
164(4):536-41 ISSN: 1073-449X
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Increased frequency of Chlamydia pneumoniae antibodies
in patients with asthma.
Gencay M, Rudiger JJ, Tamm M, Soler M, Perruchoud AP,
Roth M Am J Respir Crit Care Med (2001 Apr) 163(5):1097-100
ISSN: 1073-449X |
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Persistent airflow limitation in adult-onset nonatopic
asthma is associated with serologic evidence of Chlamydia
pneumoniae infection.
ten Brinke A, van Dissel JT, Sterk PJ, Zwinderman AH,
Rabe KF, Bel EH J Allergy Clin Immunol (2001 Mar) 107(3):449-54
ISSN: 0091-6749 |
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Detection of Mycoplasma pneumoniae in the airways
of adults with chronic asthma
[published erratum appears in Am J Respir Crit Care Med
1998 Nov;158(5 Pt 1):1692]Kraft M, Cassell GH, Henson JE,
Watson H, Williamson J, Marmion BP Gaydos CA, Martin RJ Am
J Respir Crit Care Med (1998 Sep) 158(3):998-1001 ISSN: 1073-449X
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The association of Chlamydia pneumoniae infection
and reactive airway disease in children.
Emre U, Roblin PM, Gelling M, Dumornay W, Rao M, Hammerschlag
MR Schachter J Arch Pediatr Adolesc Med (1994 Jul) 148(7):727-32
ISSN: 1072-4710 |
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Serologic markers for Chlamydia pneumoniae in
asthma.
Hahn DL, Peeling RW, Dillon E, McDonald R, Saikku P Ann
Allergy Asthma Immunol (2000 Feb) 84(2):227-33 ISSN: 1081-1206
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Chlamydia pneumoniae, asthma, and COPD: what is
the evidence?
Hahn DL Ann Allergy Asthma Immunol (1999 Oct) 83(4):271-88,
291; quiz 291-2 ISSN: 1081-1206 |
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14 |
Comparison of two serological methods and a polymerase
chain reaction- enzyme immunoassay for the diagnosis of acute
respiratory infections with Chlamydia pneumoniae in adults.
Petitjean J, Vincent F, Fretigny M, Vabret A, Poveda
JD, Brun J, Freymuth F J Med Microbiol (1998 Jul) 47(7):615-21
ISSN: 0022-2615 |
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15 |
Chlamydia pneumoniae and exacerbations of asthma
in adults.
Miyashita N, Kubota Y, Nakajima M, Niki Y, Kawane H,
Matsushima T Ann Allergy Asthma Immunol (1998 May) 80(5):405-9
ISSN: 1081-1206 |
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Association of Chlamydia pneumoniae IgA antibodies
with recently symptomatic asthma.
Hahn DL, Anttila T, Saikku P Epidemiol Infect (1996 Dec)
117(3):513-7 ISSN: 0950-2688 |
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Host immune response to Chlamydia pneumoniae heat
shock protein 60 is associated with asthma.
Huittinen T, Hahn D, Anttila T, Wahlstrom E, Saikku P,
Leinonen M Eur Respir J (2001 Jun) 17(6):1078-82 ISSN: 0903-1936
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Importance of acute Mycoplasma pneumoniae and
Chlamydia pneumoniae infections in children with wheezing
.
Esposito S, Blasi F, Arosio C, Fioravanti L, Fagetti L, Droghetti
R Tarsia P, Allegra L, Principi N Eur Respir J (2000 Dec)
16(6):1142-6 ISSN: 0903-1936 |
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Chronic Chlamydia pneumoniae infection in patients
with asthma.
Przewlekle zakazenie Chlamydia pneumoniae u chorych
na astme oskrzelowa.Niedzwiadek J, Mazur E, Chmielewska-Badora
J, Gryglicka B Wegrzyn-Szkutnik I, Chabros B, Koziol-Montewka
M, Milanowski J Pneumonol Alergol Pol (2000) 68(5-6):255-60
ISSN: 0867-7077 |
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Impact of Chlamydia pneumoniae infections on asthma.
Impact des infections a Chlamydia pneumoniae sur la maladie
asthmatique. Jebrak G, Brugiere O, Uffredi ML Presse Med (2000
Sep 9) 29(25):1425-31 ISSN: 0755-4982 |
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Chlamydia pneumoniae infection in patients with
acute bronchitis and bronchial asthma.
Oshima M, Awaya Y, Fujii T, Kodomari Y, Kuwabara M Arerugi
(2000 May) 49(5):412-9 ISSN: 0021-4884 |
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Chlamydia pneumoniae serological status is not
associated with asthma in children or young adults.
Mills GD, Lindeman JA, Fawcett JP, Herbison GP, Sears
MR Int J Epidemiol (2000 Apr) 29(2):280-4 ISSN: 0300-5771
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Production of basic fibroblast growth factor and
interleukin 6 by human smooth muscle cells following infection
with Chlamydia pneumoniae.
Rodel J, Woytas M, Groh A, Schmidt KH, Hartmann M, Lehmann
M, Straube E Infect Immun (2000 Jun) 68(6):3635-41 ISSN: 0019-9567
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The role of atypical organisms in asthma.
Daian CM, Wolff AH, Bielory L Allergy Asthma Proc (2000
Mar-Apr) 21(2):107-11 ISSN: 1088-5412 |
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Serological evidence of infection with Chlamydia
pneumoniae is related to the severity of asthma.
Black PN, Scicchitano R, Jenkins CR, Blasi F, Allegra
L, Wlodarczyk J Cooper BC Eur Respir J (2000 Feb) 15(2):254-9
ISSN: 0903-1936
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Acute respiratory Chlamydia pneumoniae infections
in adults. Value of direct gene amplification diagnosis.
Infections respiratoires aigues de l'adulte a Chlamydia pneumoniae.
Interet du diagnostic direct par amplification genique.
Vincent F, Petitjean J, Filmont JE, Le Moel G, Fontaine
V, Vabret A Freymuth F, Brun J Rev Mal Respir (1999 Dec) 16(6):1131-7
ISSN: 0761-8425
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27 |
Detection of viral, Chlamydia pneumoniae and Mycoplasma
pneumoniae infections in exacerbations of asthma in children.
Freymuth F, Vabret A, Brouard J, Toutain F, Verdon R,
Petitjean J, Gouarin S Duhamel JF, Guillois B J Clin Virol
(1999 Aug) 13(3):131-9 ISSN: 1386-6532 |
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28 |
Asthma, atopy and Chlamydia pneumoniae antibodies
in adults.
Von Hertzen L, Toyryla M, Gimishanov A, Bloigu A, Leinonen
M, Saikku P Haahtela T Clin Exp Allergy (1999 Apr) 29(4):522-8
ISSN: 0954-7894 |
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29 |
The role of viral and atypical bacterial pathogens
in asthma pathogenesis.
Johnston SL Pediatr Pulmonol Suppl (1999) 18:141-3 ISSN:
1054-187X
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30 |
Chlamydia pneumoniae and possible relationship
to asthma. Serum immunoglobulins and histamine release in
patients and controls.
Larsen FO, Norn S, Mordhorst CH, Skov PS, Milman N, Clementsen
P APMIS (1998 Oct) 106(10):928-34 ISSN: 0903-4641 |
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31 |
Chlamydia pneumoniae infection in children with
asthma exacerbation.
Kamesaki S, Suehiro Y, Shinomiya K, Matsushima H, Ouchi
K Arerugi (1998 Jul) 47(7):667-73 ISSN: 0021-4884 |
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Chlamydia pneumoniae and asthma.
Cook PJ, Davies P, Tunnicliffe W, Ayres JG, Honeybourne
D, Wise R Thorax (1998 Apr) 53(4):254-9 ISSN: 0040-6376 |
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33 |
Construction of an internal control for the detection
of Chlamydia pneumoniae by PCR.
Ursi D, Ieven M, Van Bever HP, Goossens H Mol Cell Probes
(1998 Aug) 12(4):235-8 ISSN: 0890-8508 |
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Clinical aspects of chlamydia respiratory tract
infections and their role in the pathogenesis of asthma.
Kliniczne aspekty chlamydiowych zaka~zen ukladu oddechowego
i ich rola w patogenezie astmy.Szulakowski P, Pierzchala W
Wiad Lek (1998) 51(3-4):202-7 ISSN: 0043-5147
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Chronic Chlamydia pneumoniae infection and asthma
exacerbations in children.
Cunningham AF, Johnston SL, Julious SA, Lampe FC, Ward
ME Eur Respir J (1998 Feb) 11(2):345-9 ISSN: 0903-1936 |
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36 |
Asthma and Chlamydia pneumoniae. A future prospect
for macrolides in general and roxithromycin in particular?
Asthme et Chlamydia pneumoniae. Une perspective d'avenir pour
les macrolides en general et pour la roxithromycine en particulier?Mayaud
C
Presse Med (1997 Mar) 26 Suppl 2:27-9 ISSN: 0755-4982
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Chlamydiae as pathogens: new species and new issues.
Peeling RW, Brunham RC Emerg Infect Dis (1996 Oct-Dec)
2(4):307-19 ISSN: 1080-6040 |
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38 |
Serology of chlamydia in relation to asthma and
bronchial hyperresponsiveness.
Bjornsson E, Hjelm E, Janson C, Fridell E, Boman G Scand
J Infect Dis (1996) 28(1):63-9 ISSN: 0036-5548 |
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40 |
Chlamydia pneumoniae, clarithromycin, and severe
asthma.
Kroegel C, Rodel J, Mock B Chest (2001 Sep) 120(3):1035-6
ISSN: 0012-3692 |
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Is Chlamydia pneumoniae important in asthma? The
first controlled trial of therapy leaves the question unanswered.
Johnston SL Am J Respir Crit Care Med (2001 Aug 15) 164(4):513-4
ISSN: 1073-449X |
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42 |
Chlamydia pneumoniae antibodies and adult-onset
asthma
Hahn DL J Allergy Clin Immunol (2000 Aug) 106(2):404
ISSN: 0091-6749 |
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43 |
What determines asthma phenotype? Respiratory
infections and asthma.
Douglass JA, O'Hehir RE Am J Respir Crit Care Med (2000
Mar) 161(3 Pt 2):S211-4 ISSN: 1073-449X |
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Miscellaneous Articles |
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70 |
Chlamydia pneumoniae
bacteria.
by Nancy Humphrey |
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71 |
Evidence is accumulating that many
chronic ailments, including one that kills, are caused by
bacteria
Scanned in from "The Economist" - 21st March
1998 |
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72 |
Antibiotic slows atherosclerosis
in people with Chlamydia pneumonia antibodies.
American Heart association |
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73 |
Pneumonia Organism May Play Role in MS Development.
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